The Turku Elderly Study

Health and functioning of the elderly and the oldest-old

Trends, predictors of health, functioning, longevity, mortality, and institutionalization

Medicine

Räihä I, Isoaho R, Ojanlatva A, Viramo P, Sulkava R, Kivelä S-L: Poor performance in the Mini-Mental State Examination due to causes other than dementia. Scand J Prim Health Care 2001;19:34-38.

Wendelin-Saarenhovi M, Isoaho R, Hartiala J, Helenius H, Kivelä S-L, Hietanen E: Long term reproducibility of ambulatory blood pressure in unselected elderly subjects. Clin Physiol 2001;21:316-322.

Järvenpää T, Rinne J, Räihä I, Koskenvuo M, Löppönen M, Hinkka S, Kaprio J. Characteristics of two telephone screens for cognitive im-pairment. Dement Geriatr Cogn Disord 2002;113:149-155.

Wendelin-Saarenhovi ML, Isoaho RE, Hartiala JJ, Helenius HY, Kivelä S-L, Löppönen MK, Hietanen EK: Ambulatory blood pressure charac-teristics in normotensive and treated hypertensive older people. J Hum Hypertens 2002;16:177-84.

Wasén E, Suominen P, Isoaho R, Mattila K, Virtanen A, Kivelä S-L, Irjala K: Serum cystatin C as a marker of kidney dysfunction in an elderly population. Clin Chemistry 2002;48:1138-1140.

Takala T, Suominen P, Isoaho R, Kivelä S-L, Löppönen M, Peltola O, Rajamäki A, Irjala K: Iron-replete reference intervals to increase sensi-tivity of hematologic and iron status laboratory tests in the elderly. Clin Chemistry 2002;48:1586-1589.

Linjakumpu T, Hartikainen S, Klaukka T, Koponen H, Kivelä S-L, Isoaho R: Psychotropics among the elderly – increasing trends. Int J Geriatr Psychiatry 2002;17:874-883.

Linjakumpu T, Hartikainen S, Klaukka T, Veijola J, Kivelä S-L, Isoaho R: Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol 2002;55:809-817.

Wendelin-Saarenhovi M; Isoaho R; Hartiala J; Helenius H; Kivelä S-L; Löppönen M; Puolijoki H; Hietanen E: Ambulatory blood pressure and left ventricular mass in older age. Scand J Clin Lab Invest 2002;62:569-77.

Loikas S, Löppönen M, Suominen P, Møller J, Irjala K, Isoaho R, Kivelä S-L, Koskinen P, Pelliniemi T-T: RIA for serum holo-transcobalamin: method evaluation in the clinical laboratory and reference interval. Clin Chemistry 2003;49:455-462.

Linjakumpu T, Hartikainen S, Klaukka T, Koponen H, Kivelä S-L, Isoaho R: A model to classify the sedative load of drugs. Int J Geriatr Psy-chiatry 2003;18:542-544.

Wasén E, Isoaho R, Mattila K, Vahlberg T, Kivelä S-L, Irjala K: Serum cystatin C in the aged: Relationships with health status. Am J Kidney Dis 2003;42:36-43

Hartikainen S, Ahto M, Löppönen M, Puolijoki H, Laippala P, Ojanlatva A, Kivelä S-L, Isoaho R: Change in the prevalence of coronary heart disease among Finnish elderly men and women in the 1990s. Scand J Prim Health Care 2003;21:178-181.

Löppönen M, Räihä I, Isoaho R, Kivelä S-L: Diagnosing cognitive impairment and dementia in primary health care – a more active ap-proach is needed. Age Ageing 2003;32:606-612.

Wasén E, Isoaho R, Mattila K, Vahlberg T, Kivelä S-L, Irjala K: Estimation of glomerular filtration rate in the elderly: a comparison of creati-nine-based formulae with serum cystatin C. J Int Med 2004;256:70-78.

Löppönen M, Isoaho R, Räihä I, Vahlberg T, Loikas S, Takala T, Puolijoki H, Irjala K, Kivelä S-L: Undiagnosed diseases in patients with de-mentia – a potential target group for intervention. Dementia Geriatr Cogn Disord 2004;18:321-329.

Wasén E, Isoaho R, Mattila K, Vahlberg T, Kivelä S-L, Irjala K: Renal impairment associated with diabetes in the elderly. Diabetes Care 2004;27:2648-2653.

Linjakumpu T, Hartikainen S, Klaukka T, Koponen H, Hakko H, Viilo K, Haapea M, Kivelä S-L, Isoaho R: Sedative drug use in the home-dwelling elderly. Ann Pharmacotherapy 2004;38:2017-2022.

Teinonen T, Vahlberg T, Isoaho R, Kivelä S-L: Religious attendance and 12-year survival in older persons. Age Ageing 2005;34:406-409.

Salminen M, Isoaho R, Vahlberg T, Ojanlatva A, Kivelä S-L: Effects of a health advocacy, counseling, and activation programme on depres-sive in older coronary heart disease patient. Int J Geriatr Psychiatry 2005;20:552-558.

Salminen M, Isoaho R, Vahlberg T, Ojanlatva A, Irjala K, Kivelä S-L: Effects of health advocacy, counseling, and activation among older cor-onary heart disease (CHD) patients. Aging Clinical and Experimental Research 2005;17:472-478.

Eskelinen S., Suominen P., Vahlberg T., Löppönen M., Isoaho R., Kivelä S.-L., Irjala K: The effect of thyroid antibody positivity on reference intervals for thyroid stimulating hormone (TSH) and free thyroixine (FT4) in an aged population. Clinical Chemistry Lab Med 200;43:1380-1385.

Eskelinen S, Isoaho R, Kivelä S-L, Irjala K: Actual practice vs. quidelines in laboratory monitoring of older patients with primary hypothy-roidism in primary care. Aging Clin Exp Res 2006;18:34-39.

Löppönen M, Räihä I, Isoaho R, Vahlberg T, Puolijoki H, Kivelä S-L: Dementia associates with undermedication of cardiovascular diseases in the eldelrly – a population-based study. Dement Geriatr Cogn Disord 2006;22:13-141.

Loikas S, Koskinen P, Irjala K, Löppönen M, Isoaho R, Kivelä S-L: Vitamin B12 deficinecy in the aged: a population-based study. Age and Ageing 2007;36:177-183.

Loikas S, Koskinen P, Irjala K, Löppönen M, Isoaho R, Kivelä S-L, Pelliniemi T-T: Renal impairment compromises the use of total homocys-teine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged. Clin Chem Lab Med 2007;45:197-201.

Eskelinen S, Vahlberg T, Isoaho R, Kivelä S-L, Irjala K. Biochemical reference intervals for sex hormones with a new AutoDelfia method in aged men. Clin Chem Lab Med 2007;45:249-253.

Piirtola M, Vahlberg T, Isoaho R, Kivelä S-L: Incidence of fractures and changes over time among the aged in the Finnish municipality: a population-based 12-year follow-up. Aging Clin Exp Res 2007;19:269-76.

Ahto M, Isoaho R, Puolijoki H, Vahlberg T, Kivelä S-L: Stronger symptoms of depression predict high coronary heart disease mortality in older men and women. Int J Geriatr Psychiatry 2007;22:757-763.

Eskelinen SI, Vahlberg TJ, Isoaho RE, Löppönen MK, Kivelä S-L, Irjala KM. Associations of thyroid-stimulating hormone and free thyroxine concentrations with health and life satisfaction in elderly adults. Endocr Pract. 2007;13:451-457.

Wendelin-Saarenhovi M, Isoaho R, Hartiala J, Kivelä S-L, Helenius H, Löppönen M, Puolijoki H, Hietanan E: Abulatory blood pressure associations with coronary heart diseasein the aged Finnish population. Aging Clin Exp Res 2007;19:432-437.

Eskelinen S, Vahlberg T, Isoaho R, Kivelä S-L, Irjala K. Associations of sex hormone concentrations with health and life satisfaction in elderly men. Endocrine Practice 2007;13:743-749.

Piirtola M, Vahlberg T, Isoaho R, Aarnio P, Kivelä S-L. Predictors of fractures among the aged: a population-based study with 12-year follow-up in a Finnish municipality. Aging Clin Exp Res 2008;20:242-252.

Wasén E, Isoaho R, Vahlberg T, Kivelä S-L, Irjala K. Association between markers of renal function and C-reactive protein level in the elderly: Confounding by functional status. Scand J Clin Lab Invest. 2008;68:484-491.

Piirtola M, Vahlberg T, Löppönen M, Räihä I, Isoaho R, Kivelä S-L. Fractures as predictors of excess mortality in the aged-A population-based study with a 12-year follow-up. Eur J Epidemiol 2008;23:747-755.

Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Kivela S-L: Psychotropic drugs and the risk of fractures in old age: a prospective popula-tion-based study. BMC Public Health 2010;10:396-405.

Salminen M, Kuoppamäki M, Vahlberg T, Räihä I, Irjala K, Kivelä S-L. The metabolic syndrome defined by modified International Diabetes Federation criteria and mortality: a 9-year follow-up study among the aged in Finland. Diabetes & Metab 2010;36:437–442.

Salminen M, Kuoppamäki M, Vahlberg T, Räihä I, Irjala K, Kivelä S-L. Metabolic syndrome and vascular risk: a 9-year follow-up among the aged in Finland. Acta Diabetol 2011;48:157–165.

Puustinen J, Nurminen J, Vahlberg T, Lyles A, Isoaho R, Räihä I, Kivelä SL. CNS medications as predictors of precipitous cognitive decline in the cognitively disabled aged: a longitudinal population-based study. Dement Geriatr Cogn Dis Extra 2012;2:57-68.

Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Lyles A, Kivelä S-L. Opioids, antiepileptic and anticholinergic drugs and the risk of frac-tures in patients 65 years of age and older: A prospective population-based study. Age Ageing 2012:41:1-6.

Salminen M, Kuoppamäki M, Vahlberg T, Räihä I, Irjala K, Kivelä S-L. Metabolic syndrome defined by modified International Diabetes Federation criteria and type 2 diabetes risk: a 9-year follow-up among the aged in Finland. Diabetes Vasc Dis Res 2013;10:11-6.

Linna M, Ahotupa M, Löppönen MK, Irjala K, Vasankari T. Circulating oxidised LDL lipids, when proportioned to HDL-c, emerged as a risk factor of all-cause mortality in a population-based survival study. Age Ageing 2013;42:110-13.

Salminen M, Kuoppamäki M, Vahlberg T, Räihä I, Irjala K, Kivelä S-L. Metabolic syndrome defined by modified International Diabetes Federation criteria and type 2 diabetes risk: a 9-year follow-up among the aged in Finland. Diabetes Vasc Dis Res 2013;10:11-16.

Salminen M, Kuoppamäki M, Vahlberg T, Räihä I, Irjala K, Kivelä S-L. Does high sensitive CRP improve cardiovascular risk prediction in metabolic syndrome among the aged? Scandinavian Cardiovasc J 2013;47:210-216.

Nurminen J, Puustinen J, Piirtola M, Vahlberg T, Lyles A, Kivelä S-L. Opioids, antiepileptic and anticholinergic drugs and the risk of frac-tures in patients 65 years of age and older: a prospective population-based study. Age Ageing 2013;42:318-324.

Salminen M, Vahlberg T, Räihä I, Kivelä S-L, Irjala K. Sex hormones and cardiovascular risk: a 9-year follow-up among older men in Finland. Eur Geriatr Med 2014;5:131-132.
Virtanen R, Kryssi V, Vasankari T, Salminen M, Kivelä S-L, Airaksinen JKE. Patient education to pulse palpation in self-detection of atrial fibrillation in elderly population – The LietoAF Study. Eur J Prev Cardiol 2014;21:1437-1442.

Kuoppamäki M, Salminen M, Vahlberg T, Irjala K, Kivelä S-L, Räihä I. High sensitivity C-reactive protein (hsCRP), cardiovascular events and mortality. Archives of Gerontol Geriatr 2015;60:112-117.

Salminen M, Vahlberg T, Räihä I, Niskanen L, Kivelä S-L, Irjala K. Sex hormones and type 2 diabetes mellitus: a 9-year follow-up among elderly men in Finland. Geriatrics and Gerontology International 2015;15:559-564.

Salminen M, Vahlberg T, Räihä I, Kivelä S-L, Irjala K. Sex hormone levels did not predict mortality in older Finnish men. Geriatr Gerontol Int 2016;16:146-148.

Salminen M, Laine K, Korhonen P, Wasen E, Vahlberg T, Isoaho R, Kivelä S-L, Löppönen M, Irjala K. Biomarkers of kidney function and prediction of death from cardiovascular and other causes in the elderly: a 9-year follow-up study. Eur J Intern Med in 2016;33:98-101.

Jaakkola J, Virtanen R, Vasankari T, Salminen M, Kivelä S-L, Airaksinen J. Self-detection of atrial fibrillation in an aged population: three-year follow-up of the LietoAF Study. BMC Geriatrics 2017;17:218.

Salminen M, Viljanen A, Eloranta S, Viikari P, Wuorela M, Vahlberg T ym. Frailty and mortality: an 18-year follow-up study among Finnish community-dwelling older people. Aging Clin Exp Res 2019. doi: 10.1007/s40520-019-01383-4.

Lavonius S, Salminen M, Vahlberg T, Isoaho R, Kivelä S-L, Wuorela M, Löppönen M, Viikari L. Psychosocial resources related to survival among non-robust community-dwelling older people: an 18-year follow-up study. Eur Geriatr Med 2020. doi: 10.1007/s41999-020-00300-7

Viljanen A, Salminen M, Korhonen P, Irjala K, Wuorela M, Isoaho R, Kivelä S-L, Viitanen M, Löp-pönen M, Viikari L. Frailty, walking ability and self-rated health predicting institutionalization; an 18-year follow-up among Finnish community-dwelling older people. Aging Clin Exp Res 2020. doi: 10.1007/s40520-020-01551-x

Heikkilä E, Salminen M, Viljanen A et al. A practical laboratory index to predict institutionalization and mortality – an 18-year population-based follow-up study. BMC Geriatrics 2021. In press.