Baseline: 1991 (February) – 1994 (March)
First follow-up: 1993 (May) – 1996 (May)
Second follow-up: 1995 (April) – 1998 (May)
Third follow-up: 1997 (April) – 2000 (May)
Fourth follow-up: 1999 (December) – 2002 (March)
1.016
70+
70+
Through a questionnaire, information was obtained about history of diseases and medication, as well as several other items regarding lifestyle, such as exercise, smoking, alcohol intake, education and social network. Participants also completed a 7-day food intake recording.
Information was also collected from measurements of cardiac function and structure, as well as evaluation of atherosclerosis by ultrasound and MRI. Detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function tests were also completed. Anthropomorphic measures were taken.
Blood samples were collected.
The major measurements performed at age 70 were repeated at age 75. Through a questionnaire, information was obtained about history of diseases and medication, as well as several other items regarding lifestyle, such as exercise, smoking, alcohol intake, education and social network. Participants also completed a 7-day food intake recording.
In addition, cognitive function tests were completed, such as the Mini-Mental State Exam.
Information was also collected from brain and myocardial MRIs. Detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function tests were also completed. Anthropomorphic measures were taken.
Blood samples were collected.
Through a questionnaire, information was obtained about history of diseases and medication, as well as several other items regarding lifestyle, such as exercise, smoking, alcohol intake, education and social network. Participants also completed a 7-day food intake recording.
In addition, cognitive function tests were completed, such as the Mini-Mental State Exam.
Information was also collected from brain and myocardial MRIs. Detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function tests were also completed. Anthropomorphic measures were taken.
Blood samples were collected.
Data was merged with official health databases at this stage.
Longitudinal
Questionnaires, cognitive measures, physical measures, biosamples (blood), administrative databases (health databases; vital statistics databases)
Pathogenesis of atherosclerosis
The primary aim of the PIVUS study was to study the pathogenesis of atherosclerosis and its related diseases by investigating the predictive power of different measurements of endothelial function and arterial compliance regarding future cardiovascular events. As secondary aims, the study also included measurements of cardiac function and structure by ultrasound and MRI, evaluation of atherosclerosis by ultrasound and MRI, 7-day food intake recordings, detailed ECG analysis, cardiovascular autonomic function, body composition by DXA, DNA analysis and lung function, cognitive function tests, as well as a number of biochemical markers.
Medicine
Uppsala University, Department of Medical Sciences
Prof. Lars Lind
lars.lind@medsci.uu.se
https://www.medsci.uu.se/pivus
Lind L, Fors N, Hall J, Marttala K, Stenborg A. A comparison of three different methods to evaluate endothelium-dependent vasodilation in the elderly: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Arterioscler Thromb Vasc Biol. 2005;25(11):2368-2375.