2 Waves
Wave 1:2002-2006
Wave 2:2007-2011
5746
67+ (born between 1907 and 1935)
67+ (born between 1907 and 1935)
Quantitative: questionnaires
Longitudinal
Cognitive measures, physical measures, biosamples
Others : MRI, CT scan, ultrasound
Understanding genetic and environmental contributions could create novel opportunities to prevent disease and limit disability. To address this unique opportunity. Examining genetic susceptibility and gene/environment interaction as these contribute to phenotypes common in old age.
To identify genetic and other new risk factors for selected diseases and conditions including: atherosclerosis, cognitive impairment, dementia and subtypes (i.e. Alzheimer’s disease), stroke, sarcopenia, obesity, osteoporosis, diabetes, and osteoarthritis;
To characterize phenotypes for these diseases and conditions, and study them in relation to genetic susceptibility, gene function and genetic/environmental contributions to disease;
To identify contributory molecular markers associated with these conditions including markers of cellular maintenance and repair, markers of oxidative stress, and immunologic and endocrine indicators.
Medicine
Harris TB, Launer LJ, Eiriksdottir G, et al. Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. American journal of epidemiology, 2007; 165(9): 1076-87.